סיכום
עוצמת תאי SC במחקרים הרפואיים צוברים תאוצה ,כמו כן SC בגובלת תאפשר נדבך נוסף וצוהר להצלחה.
הנדסה ביולוגית של הקרנית נהיית שימושית מיום ליום ובמיוחד אצל עיוורים יתכן שבעתיד תהיה השתלה של תאי רשתית או תאי עצבים .
מקורות
Steele C. Corneal Wound Healing; Optometry Today September 24 1999; 28-32
Dua HS, Forrester JV. The corneoscleral limbus in human corneal epithelial wound healing. Am J Ophthalmol 1990 Dec 15; 110(6): 646-56.
Lee G. Creating and growing body parts; Innovation Magazine 2002;vol 2,no. 3
A Bongso, CY Fong, SC Ng and S Ratnam. Isolation and culture of inner cell mass cells from human blastocysts. Human Reproduction 1994; 9: 2110-2117.
Jones JM, Thomson JA. Human embryonic stem cell technology. Semin Reprod Med 2000; 18(2): 219-23.
Miller F et al. Accesible stem cells. Nature Cell Biology; September 2001
Ronge’ L J; Cornea; Stem Cell Corneal transplants; AAO Magazine; August 2001.
Dua HS, Saini JS, Azuara-Blanco A & Gupta P (2000): Limbal stem cell deficiency: concept, aetiology, clinical presentation, diagnosis and management. Indian J Ophthalmol 48: 83-92.
Grueterich M, Espana EM, Touhami A, Ti SE, Tseng SC. Phenotypic study of a case with successful transplantation of ex vivo expanded human limbal epithelium for unilateral total limbal stem cell deficiency. Ophthalmology 2002 Aug; 109(8): 1547-52.
Kenyon KR, Tseng SC. Limbal autograft transplantation for ocular surface disorders. Ophthalmology 1989 May; 96(5): 709-22; discussion 722-3.
Sangwan VS. Limbal stem cells in health and disease. Biosci Rep 2001 Aug; 21(4): 385-405.
Tsubota K, Toda I, Saito H, Shinozaki N, Shimazaki J. Reconstruction of the corneal epithelium by limbal allograft transplantation for severe ocular surface disorders. Ophthalmology 1995 Oct; 102(10): 1486-96.
Basti S, Rao SK. Current status of limbal conjunctival autograft. Curr Opin Ophthalmol August 2000; 11(4): 224-32.
Hille K et al; Ophthalmologe 2002 Jul; 99(7): 575-9.
Pellegrini G, Traverso CE, Franzi AT, Zingirian M, Cancedda R, De Luca M. Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 1997 Apr 5;349(9057):990-3
Claesson M, Armitage WJ, Fagerholm P, Stenevi U. Visual outcome in corneal grafts: a preliminary analysis of the Swedish Corneal Transplant Register. Br J Ophthalmol 2002 Feb;86(2):174-80
Tsubota K, Satake Y, Kaido M, et al. Treatment of severe ocular surface disorder with corneal stem-cell transplantation. New England Journal of Medicine 1998; 340:1697-1703.
Behrens A, Shah SB, Li L, Cote MA, Liaw LL, Sweet PM, McDonnell PJ, Chuck RS. Evaluation of a microkeratome-based limbal harvester device for limbal stem cell transplantation.cornea, 2002 Jan; 21,51-55.
Ray Jui-Fang Tsai, M.D., Lien-Min Li, B.S., and Jan-Kan Chen, Ph.D. Reconstruction of Damaged Corneas by Transplantation of Autologous Limbal Epithelial Cells. New England Journal of Medicine; Volume 343:86-93 July 13, 2000
Schwab IR, Reyes M, Isseroff RR. Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease. Cornea 2000 Jul;19(4):421-6
Thoft RA. Conjunctival transplantation. Arch Ophthalmol 1977 Aug;95(8):1425-7
Prabhasawat P, Barton K, Burkett G, Tseng SC. Comparison of conjunctival autografts, amniotic membrane grafts, and primary closure for pterygium excision. Ophthalmology 1997 Jun; 104(6): 974-85.
Dekaris I, Gabric N, Karaman Z, Mravicic I, Kastelan S. Limbal-conjunctival autograft transplantation for recurrent pterygium. Eur J Ophthalmol 2002 May-Jun;12(3):177-82
Leng TL. Vision. Culturing Eye Cells for Transplants; September 7 2001.